{"id":7477,"date":"2023-03-14T20:22:01","date_gmt":"2023-03-14T17:22:01","guid":{"rendered":"https:\/\/gfmg.ua\/new\/?p=7477"},"modified":"2023-03-23T17:00:47","modified_gmt":"2023-03-23T14:00:47","slug":"vnutrishnoutrobna-gipoksiya-ta-sdug","status":"publish","type":"post","link":"https:\/\/gfmg.ua\/en\/vnutrishnoutrobna-gipoksiya-ta-sdug\/","title":{"rendered":"In Utero Exposure to Ischemic-Hypoxic Conditions and Attention-Deficit\/Hyperactivity Disorder"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"7477\" class=\"elementor elementor-7477\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6dd7dce elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"6dd7dce\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-09b3c3b\" data-id=\"09b3c3b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bbf8adb elementor-widget__width-auto elementor-widget elementor-widget-image\" data-id=\"bbf8adb\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/gfmg.ua\/en\/\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/gfmg.ua\/wp-content\/uploads\/2023\/03\/logo_blue-1-1-1-1-2.svg\" title=\"\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3376a90 elementor-widget-tablet__width-inherit elementor-widget-mobile__width-inherit elementor-widget elementor-widget-html\" 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class=\"wpml-ls-native\">English<\/span><\/a>\n\t\t\t<\/li><\/ul>\n<\/div>\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f17a912 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"f17a912\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-577a6b2\" data-id=\"577a6b2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-97241e6 elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"97241e6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-80a9688\" data-id=\"80a9688\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e1415be elementor-widget__width-auto elementor-widget elementor-widget-heading\" data-id=\"e1415be\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">ARTICLE<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-061ba76 elementor-widget elementor-widget-theme-post-title elementor-page-title elementor-widget-heading\" data-id=\"061ba76\" data-element_type=\"widget\" data-widget_type=\"theme-post-title.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\"><a href=\"\">In Utero Exposure to Ischemic-Hypoxic Conditions and Attention-Deficit\/Hyperactivity Disorder<\/a><\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-48ed40c elementor-widget elementor-widget-spacer\" data-id=\"48ed40c\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-f581469 elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"f581469\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-887e816\" data-id=\"887e816\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4fb7386 elementor-widget elementor-widget-heading\" data-id=\"4fb7386\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Attention Deficit Hyperactivity Disorder (ADHD) is a widespread chronic childhood illness characterized by hyperactivity, inattention \/ distractivity and impulse.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a08ca46 elementor-widget elementor-widget-heading\" data-id=\"a08ca46\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Justification<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b86cd30 elementor-widget elementor-widget-heading\" data-id=\"b86cd30\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">In about half of the children, mental deviations persist into adulthood. Compounded by the fact that in parallel with ADHD, such children still have concomitant mental disorders. Many of them need intensive treatment, many need social assistance.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1755791 elementor-widget elementor-widget-heading\" data-id=\"1755791\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">However, the reasons for the development of ADHD are not fully understood. One of the theories claims that the basis of such disorders is laid still in utero, due to hypoxic conditions of the fetus. To verify this thesis, a large-scale study was conducted in the USA, the description of which we offer below.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-f9d1dd0\" data-id=\"f9d1dd0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-963bd0b elementor-widget elementor-widget-image\" data-id=\"963bd0b\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"506\" height=\"337\" src=\"https:\/\/gfmg.ua\/wp-content\/uploads\/2023\/03\/vnutrishnoutrobnagipoksiyatasdug.jpg\" class=\"attachment-large size-large wp-image-7464\" alt=\"\u0413\u0456\u043f\u043e\u043a\u0441\u0456\u044f \u043f\u043b\u043e\u0434\u0430 \u0439 \u0441\u0438\u043d\u0434\u0440\u043e\u043c \u0433\u0456\u043f\u0435\u0440\u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0456 \u0442\u0430 \u0434\u0435\u0444\u0456\u0446\u0438\u0442\u0443 \u0443\u0432\u0430\u0433\u0438 \u0434\u0438\u0442\u0438\u043d\u0438\" srcset=\"https:\/\/gfmg.ua\/wp-content\/uploads\/2023\/03\/vnutrishnoutrobnagipoksiyatasdug.jpg 506w, https:\/\/gfmg.ua\/wp-content\/uploads\/2023\/03\/vnutrishnoutrobnagipoksiyatasdug-64x43.jpg 64w, https:\/\/gfmg.ua\/wp-content\/uploads\/2023\/03\/vnutrishnoutrobnagipoksiyatasdug-300x200.jpg 300w\" sizes=\"(max-width: 506px) 100vw, 506px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-cdd1ab4 elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"cdd1ab4\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-982c878\" data-id=\"982c878\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-04cf90a elementor-widget elementor-widget-heading\" data-id=\"04cf90a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Organization of the study\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-743da6c elementor-widget elementor-widget-heading\" data-id=\"743da6c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">464,317 medical records of children born in Kaiser Permanente Southern California in the period 1991-2005 were taken for analysis. The main criterion for the selection was the birth of a child no earlier than 28 weeks, deeply premature babies were not taken into the sample. Unproven cases of ADHD were also excluded from the study, which significantly increased the statistical reliability of the results.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c9930dc elementor-widget elementor-widget-heading\" data-id=\"c9930dc\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">As a result, it was possible to compose a group of 13,613 children who were treated for ADHD at the age of 5-11 years. The control group consisted of 68,065 of their healthy peers (at the rate of 5 children without ADHD per child with such a diagnosis).\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c535196 elementor-widget elementor-widget-heading\" data-id=\"c535196\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Subsequently, 1.5% of children from the control group were also diagnosed with ADHD (1000 patients).\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-890a284 elementor-widget elementor-widget-heading\" data-id=\"890a284\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Results and conclusions<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-f2a6e80 elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"f2a6e80\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-4a62f11\" data-id=\"4a62f11\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-181ff34 elementor-widget elementor-widget-heading\" data-id=\"181ff34\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Omitting painstaking statistical calculations, the study organizers report that they were able to track the link between the increased risk of developing ADHD and ischemic risks in the fetus.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-319f610 elementor-widget elementor-widget-heading\" data-id=\"319f610\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">The most powerful were the following:\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-641e600 elementor-widget elementor-widget-html\" data-id=\"641e600\" data-element_type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<div>\n    <ul class=\"circle_mark-list list\">\n        <li>Apgar score less than 7 points 5 minutes after birth;<\/li>\n        <li>the need for resuscitation;<\/li>\n        <li>pelvic or transverse presentation at the time of the onset of labor;<\/li>\n        <li>entwining the neck with an umbilical cord;<\/li>\n        <li>severe gestosis, eclampsia in the mother.<\/li>\n    <\/ul>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3b73c9a\" data-id=\"3b73c9a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5c2f04d elementor-widget elementor-widget-image\" data-id=\"5c2f04d\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"400\" height=\"272\" src=\"https:\/\/gfmg.ua\/wp-content\/uploads\/2023\/03\/vnutrishnoutrobnagipoksiyatasdug1.jpg\" class=\"attachment-large size-large wp-image-7467\" alt=\"\u0413\u0456\u043f\u043e\u043a\u0441\u0456\u044f \u043f\u043b\u043e\u0434\u0430 \u0439 \u0441\u0438\u043d\u0434\u0440\u043e\u043c \u0433\u0456\u043f\u0435\u0440\u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0456 \u0442\u0430 \u0434\u0435\u0444\u0456\u0446\u0438\u0442\u0443 \u0443\u0432\u0430\u0433\u0438 \u0434\u0438\u0442\u0438\u043d\u0438\" srcset=\"https:\/\/gfmg.ua\/wp-content\/uploads\/2023\/03\/vnutrishnoutrobnagipoksiyatasdug1.jpg 400w, https:\/\/gfmg.ua\/wp-content\/uploads\/2023\/03\/vnutrishnoutrobnagipoksiyatasdug1-64x44.jpg 64w, https:\/\/gfmg.ua\/wp-content\/uploads\/2023\/03\/vnutrishnoutrobnagipoksiyatasdug1-300x204.jpg 300w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-ff09a54 elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"ff09a54\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-1d5c9ba\" data-id=\"1d5c9ba\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-64a05fb elementor-widget elementor-widget-heading\" data-id=\"64a05fb\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Researchers were unable to establish a relationship between situations with early placental abruption and the development of ADHD.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56ed516 elementor-widget elementor-widget-heading\" data-id=\"56ed516\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Overall, among children with ADHD, 24% experienced hypoxic conditions in the antenatal period. In the control group, without mental deviations, ischemic events were observed in 20.9%.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-87c6c69 elementor-widget elementor-widget-heading\" data-id=\"87c6c69\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">These figures make it possible to assert the effect of fetal ischemia on the risk of subsequent development of a hyperactivity disorder \/ attention deficit disorder in a child.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-490e09e elementor-widget elementor-widget-heading\" data-id=\"490e09e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">However, there is no evidence to suggest that hypoxia is the only risk factor for ADHD. Which once again confirms the polyetiology of this pathology.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-26ae625 elementor-align-right btn_ico elementor-widget elementor-widget-button\" data-id=\"26ae625\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/pediatrics.aappublications.org\/content\/131\/1\/e53\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"38\" height=\"8\" viewBox=\"0 0 38 8\" fill=\"none\"><path fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M37.028 4.20659C37.413 4.02711 37.413 3.47974 37.028 3.30026L30.053 0.0482401C29.6553 -0.137218 29.2286 0.243158 29.3674 0.65952L29.9487 2.40332C29.9655 2.45363 29.9782 2.50511 29.9867 2.55727L0 2.55727L0 4.55728L29.9895 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