{"id":7543,"date":"2023-03-15T15:07:36","date_gmt":"2023-03-15T12:07:36","guid":{"rendered":"https:\/\/gfmg.ua\/new\/?p=7543"},"modified":"2023-03-23T16:49:53","modified_gmt":"2023-03-23T13:49:53","slug":"klinichna-kartina-j-likuvannya-sgb-infektsiji","status":"publish","type":"post","link":"https:\/\/gfmg.ua\/en\/klinichna-kartina-j-likuvannya-sgb-infektsiji\/","title":{"rendered":"Clinic and treatment of GBS infection in newborns"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"7543\" class=\"elementor elementor-7543\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4c7b8e3 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"4c7b8e3\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container 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elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"1e438de\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-eb4e54b\" data-id=\"eb4e54b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6bcd293 elementor-widget__width-auto elementor-widget elementor-widget-heading\" data-id=\"6bcd293\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">ARTICLE<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-87d4e05 elementor-widget elementor-widget-theme-post-title elementor-page-title elementor-widget-heading\" data-id=\"87d4e05\" data-element_type=\"widget\" data-widget_type=\"theme-post-title.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\"><a href=\"\">Clinic and treatment of GBS infection in newborns<\/a><\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb7dc94 elementor-widget elementor-widget-spacer\" data-id=\"bb7dc94\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-6e19b0a elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"6e19b0a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-8429f4a\" data-id=\"8429f4a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dcf57f5 elementor-widget elementor-widget-heading\" data-id=\"dcf57f5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Even in developed countries, the infection of streptococcus b (GBS) in newborns, gives doctors many problems. In <a href=\"https:\/\/gfmg.ua\/en\/profilaktika-infektsiji-streptokoka-b-u-novonarodzhenikh\/\" class=\"link\">our previous publication<\/a>, we have already considered what measures to prevent streptococcal infection offers the American Academy of Pediatrics. The current material will focus on recommendations for the diagnosis and treatment of this serious disease.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ee6016 elementor-widget elementor-widget-heading\" data-id=\"8ee6016\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Clinical presentation\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f53bc65 elementor-widget elementor-widget-heading\" data-id=\"f53bc65\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Newborn infants with GBS EOD may present with signs of illness ranging from tachycardia, tachypnea, or lethargy to severe cardiorespiratory failure, persistent pulmonary hypertension of the newborn, and perinatal encephalopathy. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8af7aa6 elementor-widget elementor-widget-heading\" data-id=\"8af7aa6\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">GBS LOD most commonly occurs as bacteremia without a focus and is often characterized by fever (\u226538\u00b0C) as well as lethargy, poor feeding, irritability, tachypnea, grunting, or apnea. Infants with LOD meningitis can also have nonspecific signs such as irritability, poor feeding, vomiting, and temperature instability as well as signs suggestive of central nervous systems involvement such as bulging fontanelle or seizures. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7bc5b50 elementor-widget elementor-widget-heading\" data-id=\"7bc5b50\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Focal syndromes such as pneumonia, bone or joint infection, cellulitis, or adenitis often have findings that point to the site of infection. Osteomyelitis frequently is insidious and may not be associated with fever. Complications are common for meningitis and can include neurodevelopment impairment, hearing loss, persistent seizure disorders, or cerebrovascular disease.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b8d6c92 elementor-widget elementor-widget-heading\" data-id=\"b8d6c92\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Evaluation for GBS disease is the same as that for all forms of sepsis in the newborn and young infant.Blood culture, lumbar puncture for culture and analysis of CSF, and markers of inflammation are discussed in detail in the AAP clinical reports on management of neonates with suspected or proven early-onset bacterial sepsis.<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-95b8de7 elementor-widget elementor-widget-heading\" data-id=\"95b8de7\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\"> The evaluation for GBS LOD should also include urine culture. If bone or joint infection is suspected, additional studies can include radiographs, MRI, and bone or joint fluid culture. When meningitis is diagnosed, cranial imaging is often useful to assess for complications such as ventriculitis or brain abscess. Cultures should include testing for antibiotic susceptibility.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-895d07a elementor-widget elementor-widget-heading\" data-id=\"895d07a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Empirical treatment\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-07ede05 elementor-widget elementor-widget-heading\" data-id=\"07ede05\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Antibiotics initiated because of concern for GBS EOD are the same as those for all bacterial causes of EOS until the results of cultures are available. Ampicillin, together with an aminoglycoside, is the primary recommended therapy for infants up to 7 days of age. The empirical addition of broader-spectrum therapy should be considered if there is strong clinical concern for ampicillin-resistant infection in a critically ill newborn, particularly among neonates with very low birth weight.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9b152a8 elementor-widget elementor-widget-heading\" data-id=\"9b152a8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Ampicillin, together with an aminoglycoside, is the primary recommended therapy for infants up to 7 days of age. The empirical addition of broader-spectrum therapy should be considered if there is strong clinical concern for ampicillin-resistant infection in a critically ill newborn, particularly among neonates with very low birth weight.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cdd115e elementor-widget elementor-widget-heading\" data-id=\"cdd115e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Among previously healthy infants in the community, if the infant is not critically ill and there is no evidence of meningitis, ampicillin and ceftazidime together are recommended as empirical therapy for those 8 to 28 days of age; ceftriaxone therapy is recommended under these circumstances for infants 29 to 90 days of age. For all previously healthy infants in the community from 8 to 90 days of age, vancomycin should be added to recommended empirical therapy if there is evidence of meningitis or critical illness to expand coverage.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-93bbdf8 elementor-widget elementor-widget-heading\" data-id=\"93bbdf8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">The choice of empirical therapy among continuously hospitalized preterm infants beyond 72 hours of age is guided by multiple factors, including the presence of central venous catheters and local hospital microbiology. The empirical choice for such infants should include an antibiotic to which group B streptococci are susceptible, such as a \u03b2-lactam, cephalosporin, or vancomycin. When group B streptococci are identified in culture, penicillin G is the drug of choice, with ampicillin as an acceptable alternative therapy.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9108e6d elementor-widget elementor-widget-heading\" data-id=\"9108e6d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Recommended Intravenous Antibiotic Treatment Regimens for Confirmed Early- and Late-Onset GBS Bacteremia and Meningitis\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-6dcef2d elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"6dcef2d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-536c825\" data-id=\"536c825\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6ede3cb elementor-widget__width-inherit elementor-hidden-mobile elementor-widget elementor-widget-html\" data-id=\"6ede3cb\" data-element_type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<div class=\"table_block table_col\">\n    <div class=\"table_row table_row-block\">\n        <div class=\"table_col table_cell-title table_cell\"><\/div>\n        <div class=\"table_col table_col-first\">\n            <div class=\"table_row table_cell\">\n                <p>GA \u226434 wk<\/p>\n            <\/div>\n            <div class=\"table_row\">\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>PNA \u22647 d<\/p>\n                <\/div>\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>PNA >7 d<\/p>\n                <\/div>\n            <\/div>\n        <\/div>\n        <div class=\"table_col\">\n            <div class=\"table_row table_cell\">\n                <p>GA >34 wk<\/p>\n            <\/div>\n            <div class=\"table_row\">\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>PNA \u22647 d<\/p>\n                <\/div>\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>PNA >7 d<\/p>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n    <div class=\"table_row table_row-full\">\n        <p>Bacteremia<\/p>\n    <\/div>\n    <div class=\"table_row  table_row-block\">\n        <div class=\"table_col table_cell table_cell-title\">\n            <p>Ampicillin<\/p>\n        <\/div>\n        <div class=\"table_col table_col-first\">\n            <div class=\"table_row\">\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>50 mg\/kg every 12 h<\/p>\n                <\/div>\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>75 mg\/kg every 12 h<\/p>\n                <\/div>\n            <\/div>\n        <\/div>\n        <div class=\"table_col\">\n            <div class=\"table_row\">\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>50 mg\/kg every 8 h<\/p>\n                <\/div>\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>50 mg\/kg every 8 h<\/p>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n    <div class=\"table_row  table_row-block\">\n        <div class=\"table_col table_cell table_cell-title\">\n            <p>Penicillin G<\/p>\n        <\/div>\n        <div class=\"table_col table_col-first\">\n            <div class=\"table_row\">\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>50.000 U\/kg every 12 h<\/p>\n                <\/div>\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>50.000 U\/kg every 8 h<\/p>\n                <\/div>\n            <\/div>\n        <\/div>\n        <div class=\"table_col\">\n            <div class=\"table_row\">\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>50.000 U\/kg every 12 h<\/p>\n                <\/div>\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>50.000 U\/kg every 8 h<\/p>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n    <div class=\"table_row table_row-full\">\n        <p>Meningitis<\/p>\n    <\/div>\n    <div class=\"table_row  table_row-block\">\n        <div class=\"table_col table_cell table_cell-title\">\n            <p>Ampicillin<\/p>\n        <\/div>\n        <div class=\"table_col table_col-first\">\n            <div class=\"table_row\">\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>100 mg\/kg every 8 h<\/p>\n                <\/div>\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>75 mg\/kg every 6 h<\/p>\n                <\/div>\n            <\/div>\n        <\/div>\n        <div class=\"table_col\">\n            <div class=\"table_row\">\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>100 mg\/kg every 8 h<\/p>\n                <\/div>\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>75 mg\/kg every 6 h<\/p>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n    <div class=\"table_row table_row-block\">\n        <div class=\"table_col table_cell table_cell-title\">\n            <p>Penicillin G<\/p>\n        <\/div>\n        <div class=\"table_col table_col-first\">\n            <div class=\"table_row\">\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>150.000 U\/kg every 8 h<\/p>\n                <\/div>\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>125.000 U\/kg every 6 h<\/p>\n                <\/div>\n            <\/div>\n        <\/div>\n        <div class=\"table_col\">\n            <div class=\"table_row\">\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>150.000 U\/kg every 8 h<\/p>\n                <\/div>\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>125 \u041e\u0434 \/ \u043a\u0433 \u043a\u043e\u0436\u043d\u0456 6 \u0433\u043e\u0434<\/p>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-76a5596 elementor-widget__width-inherit elementor-hidden-desktop elementor-hidden-tablet elementor-widget elementor-widget-html\" data-id=\"76a5596\" data-element_type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<div class=\"table_block table_col\">\n    <div class=\"table_row table_row-block\">\n        <div class=\"table_col table_col-first\">\n            <div class=\"table_row table_cell\">\n                <p>GA \u226434 wk<\/p>\n            <\/div>\n        <\/div>\n    <\/div>\n    <div class=\"table_row table_row-full\">\n        <p>Bacteremia<\/p>\n    <\/div>\n    <div class=\"table_row\">\n            <div class=\"table_col table_col-50 table_cell table_cell-title\">\n                <p>Ampicillin<\/p>\n            <\/div>\n            <div class=\"table_col table_col-50 table_cell table_cell-title\">\n                <p>Penicillin G<\/p>\n            <\/div>\n        <\/div>\n    <div class=\"table_row table_cell\">\n        <div class=\"table_col  table_cell\">\n            <p>PNA \u22647 d<\/p>\n        <\/div>\n    <\/div>\n    <div class=\"table_row table_row-block\">\n        <div class=\"table_col table_col-first\">\n            <div class=\"table_row\">\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>50 mg\/kg every 12 h<\/p>\n                <\/div>\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>50.000 U\/kg every 12 h<\/p>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n    <div class=\"table_row table_cell\">\n        <div class=\"table_col  table_cell\">\n            <p>PNA >7 d<\/p>\n        <\/div>\n    <\/div>\n    <div class=\"table_col table_col-first\">\n        <div class=\"table_row\">\n            <div class=\"table_col table_col-50 table_cell\">\n                <p>75 mg\/kg every 12 h<\/p>\n            <\/div>\n            <div class=\"table_col table_col-50 table_cell\">\n                <p>50.000 U\/kg every 8 h<\/p>\n            <\/div>\n        <\/div>\n    <\/div>\n    <div class=\"table_row table_row-full\">\n        <p>Meningitis<\/p>\n    <\/div>\n    <div class=\"table_row\">\n            <div class=\"table_col table_col-50 table_cell table_cell-title\">\n                <p>Ampicillin<\/p>\n            <\/div>\n            <div class=\"table_col table_col-50 table_cell table_cell-title\">\n                <p>Penicillin G<\/p>\n            <\/div>\n        <\/div>\n    <div class=\"table_row table_cell\">\n        <div class=\"table_col  table_cell\">\n            <p>PNA \u22647 d<\/p>\n        <\/div>\n    <\/div>\n    <div class=\"table_row table_row-block\">\n        <div class=\"table_col table_col-first\">\n            <div class=\"table_row\">\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>100 mg\/kg every 8 h<\/p>\n                <\/div>\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>150.000 U\/kg every 8 h<\/p>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n    <div class=\"table_row table_cell\">\n        <div class=\"table_col  table_cell\">\n            <p>PNA >7 d<\/p>\n        <\/div>\n    <\/div>\n    <div class=\"table_col table_col-first\">\n        <div class=\"table_row\">\n            <div class=\"table_col table_col-50 table_cell\">\n                <p>75 mg\/kg every 6 h<\/p>\n            <\/div>\n            <div class=\"table_col table_col-50 table_cell\">\n                <p>125.000 U\/kg every 6 h<\/p>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n<div class=\"table_block table_col\">\n    <div class=\"table_row table_row-block\">\n        <div class=\"table_col table_col-first\">\n            <div class=\"table_row table_cell\">\n                <p>GA >34 wk<\/p>\n            <\/div>\n        <\/div>\n    <\/div>\n    <div class=\"table_row table_row-full\">\n        <p>Bacteremia<\/p>\n    <\/div>\n    <div class=\"table_row\">\n            <div class=\"table_col table_col-50 table_cell table_cell-title\">\n                <p>Ampicillin<\/p>\n            <\/div>\n            <div class=\"table_col table_col-50 table_cell table_cell-title\">\n                <p>Penicillin G<\/p>\n            <\/div>\n        <\/div>\n    <div class=\"table_row table_cell\">\n        <div class=\"table_col  table_cell\">\n            <p>PNA \u22647 d<\/p>\n        <\/div>\n    <\/div>\n    <div class=\"table_row table_row-block\">\n        <div class=\"table_col table_col-first\">\n            <div class=\"table_row\">\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>50 mg\/kg every 8 h<\/p>\n                <\/div>\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>50.000 U\/kg every 12 h<\/p>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n    <div class=\"table_row table_cell\">\n        <div class=\"table_col  table_cell\">\n            <p>PNA >7 d<\/p>\n        <\/div>\n    <\/div>\n    <div class=\"table_col table_col-first\">\n        <div class=\"table_row\">\n            <div class=\"table_col table_col-50 table_cell\">\n                <p>50 mg\/kg every 8 h<\/p>\n            <\/div>\n            <div class=\"table_col table_col-50 table_cell\">\n                <p>50.000 U\/kg every 8 h<\/p>\n            <\/div>\n        <\/div>\n    <\/div>\n    <div class=\"table_row table_row-full\">\n        <p>Meningitis<\/p>\n    <\/div>\n    <div class=\"table_row\">\n            <div class=\"table_col table_col-50 table_cell table_cell-title\">\n                <p>Ampicillin<\/p>\n            <\/div>\n            <div class=\"table_col table_col-50 table_cell table_cell-title\">\n                <p>Penicillin G<\/p>\n            <\/div>\n        <\/div>\n    <div class=\"table_row table_cell\">\n        <div class=\"table_col  table_cell\">\n            <p>PNA \u22647 d<\/p>\n        <\/div>\n    <\/div>\n    <div class=\"table_row table_row-block\">\n        <div class=\"table_col table_col-first\">\n            <div class=\"table_row\">\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>100 mg\/kg every 8 h<\/p>\n                <\/div>\n                <div class=\"table_col table_col-50 table_cell\">\n                    <p>150.000 U\/kg every 8 h<\/p>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n    <div class=\"table_row table_cell\">\n        <div class=\"table_col  table_cell\">\n            <p>PNA >7 d<\/p>\n        <\/div>\n    <\/div>\n    <div class=\"table_col table_col-first\">\n        <div class=\"table_row\">\n            <div class=\"table_col table_col-50 table_cell\">\n                <p>75 mg\/kg every 6 h<\/p>\n            <\/div>\n            <div class=\"table_col table_col-50 table_cell\">\n                <p>125 U\/kg every 6 h<\/p>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1024433 elementor-widget elementor-widget-heading\" data-id=\"1024433\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Multiple Births\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9aafdce elementor-widget elementor-widget-heading\" data-id=\"9aafdce\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">When invasive GBS infection occurs in an infant who is 1 of multiple births, the birth siblings should be observed carefully for signs of infection and treated empirically if signs of illness occur. There is no evidence to support full antibiotic treatment courses in the absence of confirmed GBS disease.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-360a0e0 elementor-widget elementor-widget-heading\" data-id=\"360a0e0\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Recurrent GBS Disease\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e161dbe elementor-widget elementor-widget-heading\" data-id=\"e161dbe\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Recurrent neonatal and young infant GBS disease can occur after completed appropriate treatment of the primary infection.103,104 Authors of a population-based study conducted in Japan53 during 2011 to 2015 found that recurrence occurred in 2.8% of cases of neonatal GBS infection. Recurrent cases were identified 3 to 54 days after completion of the therapy for the first occurrence. Recurrent cases are generally caused by the same GBS serotype that caused the primary infection, and persistent mucosal colonization and poor neonatal antibody responses to the first infection likely contribute to the pathogenesis of recurrent infection. Recurrent disease is not preventable by extension of recommended antibiotic courses nor by the addition of rifampin to eradicate mucosal colonization. Parents should be counseled about the possibility of recurrent GBS disease after treatment of both GBS EOD and LOD.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9b4f616 elementor-widget elementor-widget-heading\" data-id=\"9b4f616\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Future Directions\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f314564 elementor-widget elementor-widget-heading\" data-id=\"f314564\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Intrapartum Antibiotics, the Microbiome, and Childhood Health\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-118cf4a elementor-widget elementor-widget-heading\" data-id=\"118cf4a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">GBS IAP and the administration of intrapartum antibiotics because of concern for maternal intraamniotic infection combined result in approximately 30% of pregnant women receiving antibiotics around the time of delivery. The composition of the gut microbiota develops and diversifies from birth through early childhood, and disruption of the microbiota during this critical period may have enduring health consequences. Perinatal antibiotic administration is associated with abnormal host development in animal models.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-f4b38c5 elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"f4b38c5\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-a879cbe\" data-id=\"a879cbe\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3205485 elementor-widget elementor-widget-heading\" data-id=\"3205485\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Human epidemiological studies have associated early infant antibiotic exposures with increased risks of atopic and allergic disorders as well as increases in early childhood weight gain.<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb1e1ec elementor-widget elementor-widget-heading\" data-id=\"bb1e1ec\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">GBS Vaccine Development\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ea9121 elementor-widget elementor-widget-heading\" data-id=\"8ea9121\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Multiple gaps remain in GBS disease prevention. Neonatal EOD continues to occur in the United States, primarily among preterm infants, term infants born to women with cultures negative for antenatal GBS, and infants born to mothers with reported \u03b2-lactam allergy that precludes maximally effective IAP. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f504845 elementor-widget elementor-widget-heading\" data-id=\"f504845\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">The incidence of GBS LOD has not been affected by IAP. In addition, group B Streptococcus is a cause of stillbirth and of invasive infection among pregnant and postpartum women as well as among the elderly and those whose health is compromised by diabetes or malignancy. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4effd57 elementor-widget elementor-widget-heading\" data-id=\"4effd57\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Furthermore, GBS disease is a worldwide problem, particularly among resource-limited countries where IAP is not a readily available preventive strategy. <\/p>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-f37dbc9\" data-id=\"f37dbc9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8f55a9e elementor-widget elementor-widget-image\" data-id=\"8f55a9e\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"339\" height=\"509\" src=\"https:\/\/gfmg.ua\/wp-content\/uploads\/2023\/03\/klinichnakartinajlikuvannyasgbinfektsiji3.jpg\" class=\"attachment-large size-large wp-image-7536\" alt=\"\u0412\u0430\u043a\u0446\u0438\u043d\u0430\" srcset=\"https:\/\/gfmg.ua\/wp-content\/uploads\/2023\/03\/klinichnakartinajlikuvannyasgbinfektsiji3.jpg 339w, https:\/\/gfmg.ua\/wp-content\/uploads\/2023\/03\/klinichnakartinajlikuvannyasgbinfektsiji3-64x96.jpg 64w, https:\/\/gfmg.ua\/wp-content\/uploads\/2023\/03\/klinichnakartinajlikuvannyasgbinfektsiji3-300x450.jpg 300w, https:\/\/gfmg.ua\/wp-content\/uploads\/2023\/03\/klinichnakartinajlikuvannyasgbinfektsiji3-200x300.jpg 200w\" sizes=\"(max-width: 339px) 100vw, 339px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3e0151a elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"3e0151a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-56df261\" data-id=\"56df261\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6c822de elementor-widget elementor-widget-heading\" data-id=\"6c822de\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Effective, multivalent vaccines administered to pregnant women and at-risk nonpregnant adults could potentially prevent many of these issues. Preclinical and human phase I and II studies have been completed revealing the safety and immunogenicity of glycoconjugate GBS vaccines. Current ABCs reveals that 99% of infections are caused by 6 GBS serotypes, suggesting that a hexavalent vaccine could be widely effective.\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3f3c52c elementor-align-right btn_ico elementor-widget elementor-widget-button\" data-id=\"3f3c52c\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/pediatrics.aappublications.org\/content\/early\/2019\/07\/04\/peds.2019-1881\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"38\" height=\"8\" viewBox=\"0 0 38 8\" fill=\"none\"><path fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M37.028 4.20659C37.413 4.02711 37.413 3.47974 37.028 3.30026L30.053 0.0482401C29.6553 -0.137218 29.2286 0.243158 29.3674 0.65952L29.9487 2.40332C29.9655 2.45363 29.9782 2.50511 29.9867 2.55727L0 2.55727L0 4.55728L29.9895 4.55728C29.9827 4.60402 29.9726 4.65028 29.9592 4.6957L29.3133 6.88686C29.1915 7.29984 29.6139 7.66334 30.0042 7.4814L37.028 4.20659Z\" fill=\"white\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">According to the materials of the American Academy of Pediatrics<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-c3c2ffa elementor-post-navigation-borders-yes elementor-widget elementor-widget-post-navigation\" data-id=\"c3c2ffa\" data-element_type=\"widget\" data-widget_type=\"post-navigation.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-post-navigation\">\n\t\t\t<div class=\"elementor-post-navigation__prev elementor-post-navigation__link\">\n\t\t\t\t<a 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In our previous publication, we have already considered what measures to prevent streptococcal infection offers the American Academy of Pediatrics. The current material will focus on recommendations for the diagnosis and treatment of this serious disease.<\/p>\n","protected":false},"author":2,"featured_media":7567,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_canvas","format":"standard","meta":{"footnotes":""},"categories":[58],"tags":[],"class_list":["post-7543","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Clinic and treatment of GBS infection in newborns - Geolik Farm Marketing Group<\/title>\n<meta name=\"description\" content=\"Even in developed countries, the infection of streptococcus b (GBS) in newborns, gives doctors many problems.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/gfmg.ua\/en\/klinichna-kartina-j-likuvannya-sgb-infektsiji\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Clinic and treatment of GBS infection in newborns - 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